Researchers have uncovered a surprising new role for the HSL protein: beyond breaking down fat, it also works inside the nucleus of fat cells to keep them functioning properly. When HSL is missing, fat tissue doesn’t expand as expected— instead, it shrinks, leading to lipodystrophy. This unexpected discovery helps explain why both obesity and fat-loss disorders share similar health risks, and it opens up fresh paths for understanding metabolic diseases at a time when obesity affects billions worldwide.
I expect HSL antagonists to be hitting the unregulated supplement industry pretty quickly. Then we will find that some aren’t bioavailable at all and a complete waste of money. But others will be super effective and people will start dropping from heart attacks if their kidneys don’t collapse first.
the only reason you should be taking supplements is from a direct recommendation from your doctor who can monitor the levels and have you adjust dosing accordingly. anything outside of that is more likely to do harm than good.
I have a long documented history of ranting against supplements. I am very aware. They often contain things they don’t say they do and don’t contain what they say they do. That most of it’s just expensive of urine. That you shouldn’t be taking any supplement unless specifically recommended by your doctor because a blood test showed a deficiency and you should know how to make something you take actually bioavailable. The industry is mostly a scam. And I hate going into health food stores. We’re more than half the square footage is supplements. Little pharma is trying to steal your money.