A new study suggests that dementia may be driven in part by faulty blood flow in the brain. Researchers found that losing a key lipid causes blood vessels to become overactive, disrupting circulation and starving brain tissue. When the missing molecule was restored, normal blood flow returned. This discovery opens the door to new treatments aimed at fixing vascular problems in dementia.

Ahmed M. Hashad, Mohammad M. Abd-Alhaseeb, Xin Rui Lim, Natalia M. Mathieu, Osama F. Harraz. PIP 2 corrects an endothelial Piezo1 channelopathy. Proceedings of the National Academy of Sciences, 2025; http://dx.doi.org/10.1073/pnas.2522750122

  • HisArmsOpen@crust.piefed.socialEnglish
    35·
    20 hours ago

    A promising mouse model experiment. Hopefully this can be built upon to reinforce the numbers and confidence and so to additional models.